Peptide Database

Peptide NameTachyplesin-1

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Virucidal activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC99H154N34O20S4

DescriptionStandard

        KWCFRVCYRGICYRRCR
    

Molecular Weight2268.76 Da

Isoelectric Point (pI)9.93

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3363

GRAVY Index-0.52

Hydrophobic Moment 0.65

Boman Index-0.44

Instability Index13.22

Aliphatic Index 40.00

Aromaticity 0.2353

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 920.69

LogP -6.48

H-bond Donors 41.0

H-bond Acceptors 30.0

Rotatable Bonds 72.0

Heavy Atoms 157.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0369365 VERIFIED: YES

Provenance & Taxonomy

OrganismTachypleus gigas [Animal]

FamilyTachyplesin polyphemusin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetGram-negative and Gram-positive bacteria

RECORD: Rec_0371034 VERIFIED: YES

Provenance & Taxonomy

OrganismTachypleus tridentatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis ATCC 6051

Activity0.125 μg/mL

RECORD: Rec_0387997 VERIFIED: YES

Provenance & Taxonomy

OrganismTachypleus tridentatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetNH2): Escherichia coli ATCC 25922

Activity0.5

MethodMIC

RECORD: Rec_0404739 VERIFIED: YES

Provenance & Taxonomy

OrganismTachypleus tridentatus [Animal]

FamilyTachyplesin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16, 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Anti-HIV Anticancer Hemolytic

Targethuman red blood cells

RECORD: Rec_0409354 VERIFIED: NO

Provenance & Taxonomy

OrganismTachypleus tridentatus [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial

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