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MYP_111710
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Basic Information
Tachyplesin-1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Virucidal activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C99H154N34O20S4
Standard
Sequence
KWCFRVCYRGICYRRCR
Physicochemical Analysis
2268.76 Da
9.93
5.72
5.45
0.3363
-0.52
0.65
-0.44
13.22
40.00
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.69
-6.48
41.0
30.0
72.0
157.0
5.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000259 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
NH2): Escherichia coli ATCC 25922
1-4 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0037265 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0048846 VERIFIED: NO
Provenance & Taxonomy
Horseshoe crab [Animal]; Arthropoda [Animal]
33208; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Hydroxyproline-like notation
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0063198 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus 209P
0.5 μM
MIC
PMID30486233 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30486233/
RECORD: Rec_0064552 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-16, 7-12
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Anti-HIV Anticancer Hemolytic
PMID12369825;2229025;31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12369825/
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