Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length436 amino acids

Chemical FormulaC2175H3478N578O601S15

DescriptionStandard

        MARGPDDTWRWATLLVLAALGTAVTATTNPGVVARITQKGLDYACQQGVATLQKELEKITIPTLSGSFKVKHLGKGKYSFYSLVIHGFKLPNSQIRPLPNQGLALSIKDASIKMSGKWKARKSFIKVSGNFDLSVEGISILATLKLGYDPTSGHATVACSSCSSHINSVRVRISRSSLGWLIQLFHKKIESSLRNSMNRKICEIVTSAVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADRLDGLLKGEFFRLAHRRPPPFAPPALTLPTNHNRMVYLGISEYLFNTAGLVYQEAGVLNLTLSNDMFPKKSKFFLTTTFFGTLLPQVAKMFPDMKMQLLIWAPSPPNVAVCPTGLDLTFSLDTQAVAVLPDSSLAPLFLLGMNMNISVDIRARSNRLVGELKLDKLLLKLKHSNIAHFPDFLLFGADVRYG
    

Molecular Weight47821.37 Da

Isoelectric Point (pI)9.83

Net Charge (pH 7.0)22.24

Net Charge (pH 7.4) 21.41

Charge Density (pH 7.0) 0.0510

GRAVY Index0.08

Hydrophobic Moment 0.66

Boman Index0.11

Instability Index34.60

Aliphatic Index 99.77

Aromaticity 0.0849

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42650.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0096027 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera physalus (Fin whale) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria