Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2322H3714N584O671S19

DescriptionStandard

        MSPCCWLALLALVPLALATNPGVKVKLTEKGIEYGKQIGMVSLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPNSGLALVPGTGISLSITNAFISLHGNWKIQYLSFIKDSGSFDLEVNGLTITDSITIKSDETGRPTVSSVNCGANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGISAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPGMMMKLLVKTVKEPTIFFEPNNVTVQASGTVTAYAIQPNTTLSPLFVLSMEGSVSARLYVTGVKLAGAVTLNKIEMTLETTYVGQFQVRSLDNIFLMVLKVAVIPKVNARLEKGFPLPSIGKMNLVNTQLQVLKDYMVIGTDVQFTG
    

Molecular Weight51157.07 Da

Isoelectric Point (pI)9.15

Net Charge (pH 7.0)8.83

Net Charge (pH 7.4) 8.24

Charge Density (pH 7.0) 0.0187

GRAVY Index0.21

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index27.96

Aliphatic Index 101.16

Aromaticity 0.0825

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0004874 VERIFIED: NO

Provenance & Taxonomy

OrganismHucho hucho [Bacterium]

FamilyBPI

Tax ID62062

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence