Peptide Database

Peptide NameLepirudin

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Thrombin inhibition ▸ Thrombin inhibitory

Hemostasis ▸ Anticoagulant activity

Hemostasis ▸ Antithrombotic activity

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC288H448N80O110S6

DescriptionStandard

        LVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQSHNDGDFEEIPEEYLQ
    

Molecular Weight6983.50 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-9.19

Net Charge (pH 7.4) -9.55

Charge Density (pH 7.0) -0.1414

GRAVY Index-0.78

Hydrophobic Moment 0.47

Boman Index-0.06

Instability Index48.15

Aliphatic Index 55.38

Aromaticity 0.0462

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3086.89

LogP -42.00

H-bond Donors 105.0

H-bond Acceptors 108.0

Rotatable Bonds 234.0

Heavy Atoms 484.0

Ring Count 7.0

Amide Bonds 74.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0053401 VERIFIED: YES

Provenance & Taxonomy

OrganismSaccharomyces cerevisiae [Fungus]; Hirudo medicinalis [Animal]; synthetic construct [Synthetic]

FamilyHirudin analog

Tax ID4932;6421;32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-14, 16-28, 22-39

Other ModsDesulfated Tyr63 relative to native hirudin; N-terminal Ile→Leu substitution

Bio-Activity Profile

Function

Anticoagulant Antithrombotic Direct thrombin inhibitor

Half-Lifeapprox. 1.3 h