Peptide Database

Peptide Namechassatide C12

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC135H203N35O42S6

DescriptionStandard

        EYCGESCYLIPCFTPGCYCVSRQCVNKN
    

Molecular Weight3180.66 Da

Isoelectric Point (pI)6.18

Net Charge (pH 7.0)-0.22

Net Charge (pH 7.4) -0.49

Charge Density (pH 7.0) -0.0080

GRAVY Index-0.06

Hydrophobic Moment 0.44

Boman Index0.04

Instability Index35.89

Aliphatic Index 48.57

Aromaticity 0.1429

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1244.61

LogP -13.66

H-bond Donors 48.0

H-bond Acceptors 48.0

Rotatable Bonds 97.0

Heavy Atoms 218.0

Ring Count 6.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251149 VERIFIED: YES

Provenance & Taxonomy

OrganismChassalia chartacea [Plant]

FamilyCyclotide

Tax ID137261

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antibacterial Cytotoxic Hemolytic Anti-Gram-positive

TargetStaphylococcus aureus

RECORD: Rec_0266038 VERIFIED: YES

Provenance & Taxonomy

OrganismChassalia chartacea [Plant]

FamilyCyclotide

Tax ID137261

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Cytotoxic Hemolytic

Targetand ?Escherichia coli

RECORD: Rec_0331475 VERIFIED: NO

Provenance & Taxonomy

OrganismChassalia chartacea [Plant]

FamilyCyclotide

Structure & Mods

Configbackbone-cyclized cyclotide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0427158 VERIFIED: YES

Provenance & Taxonomy

OrganismChassalia chartacea [Plant]

FamilyCyclotide

Tax ID137261

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Antimicrobial Antibacterial Cytotoxic Hemolytic Anti-Gram-positive

TargetStaphylococcus epidermidis