Peptide Database

Peptide NameCath-B

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC203H345N59O39

DescriptionStandard

        KRFKKFFRKLKKSVKKRKKEFKKKPRVIGVSIPF
    

Molecular Weight4236.28 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)15.75

Net Charge (pH 7.4) 15.53

Charge Density (pH 7.0) 0.4632

GRAVY Index-1.12

Hydrophobic Moment 0.90

Boman Index-0.50

Instability Index14.58

Aliphatic Index 60.00

Aromaticity 0.1471

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1669.66

LogP -9.06

H-bond Donors 61.0

H-bond Acceptors 55.0

Rotatable Bonds 157.0

Heavy Atoms 301.0

Ring Count 7.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057139 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetKlebsiella pneumoniae ATCC 700603

Activity32 μg/mL

MethodMIC

PaperThe antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus. J Microbiol. 2018 Feb;56(2):128-137. doi: 10.1007/s12275-018-7444-5. PMID: 29392557. PMID29392557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29392557/

RECORD: Rec_0067561 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

TargetHuman erythrocytes

Activity1000 μg/mL

MethodHemolysis

RECORD: Rec_0072665 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPS-7

Activity32 μg/mL

MethodMIC

RECORD: Rec_0074731 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetKlebsiella pneumoniae ATCC 700603

Activity32 μg/mL

MethodMIC

RECORD: Rec_0075409 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 25923

Activity32 μg/mL

MethodMIC

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