Peptide Database

Peptide NameANF (Ser103-Tyr126) (Atrial natriuretic factor )

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC106H165N35O34S3

DescriptionStandard

        SSCFGGRMDRIGAQSGLGCNSFRY
    

Molecular Weight2569.85 Da

Isoelectric Point (pI)8.94

Net Charge (pH 7.0)1.44

Net Charge (pH 7.4) 1.20

Charge Density (pH 7.0) 0.0600

GRAVY Index-0.33

Hydrophobic Moment 0.54

Boman Index-0.06

Instability Index44.82

Aliphatic Index 36.67

Aromaticity 0.1250

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1142.95

LogP -16.76

H-bond Donors 44.0

H-bond Acceptors 39.0

Rotatable Bonds 85.0

Heavy Atoms 178.0

Ring Count 3.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023025 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-19

Other ModsRadioiodinated peptide at Tyr

Bio-Activity Profile

Function

Natriuretic

MethodIC50

Half-LifeMale Sprague-Dawley rats plasma (Dose i/p injected), in vivo; 22 s

RECORD: Rec_0138712 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Sus scrofa [Animal]

Tax ID9606, 9823

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-18

Bio-Activity Profile

Function

Neuropeptide