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MYP_111441
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Basic Information
Brevinin-1BLc
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C127H208N28O27S2
Standard
Sequence
FLPIIAGIAAKFLPKIFCTISKKC
Physicochemical Analysis
2623.31 Da
9.70
3.74
3.50
0.1557
1.18
0.62
0.40
32.14
126.25
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-1.95
31.0
33.0
85.0
184.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0398155 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
cancer cells HepG2
6 μM
LC50
PaperPeptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis.
RECORD: Rec_0398813 VERIFIED: YES
Provenance & Taxonomy
Rana blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
HepG2 human hepatoma-derived cells
6 μM
LC50
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0418081 VERIFIED: NO
Provenance & Taxonomy
America leopard [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0422575 VERIFIED: YES
Provenance & Taxonomy
Rana blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
1.5 μM
MIC
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0423388 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Candida albicans
3 μM
MIC
PaperPeptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis.
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