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MYP_111441
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Basic Information
Brevinin-1BLc
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C127H208N28O27S2
Standard
Sequence
FLPIIAGIAAKFLPKIFCTISKKC
Physicochemical Analysis
2623.31 Da
9.70
3.74
3.50
0.1557
1.18
0.62
0.40
32.14
126.25
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-1.95
31.0
33.0
85.0
184.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0136863 VERIFIED: NO
Provenance & Taxonomy
Rana blairi [Animal]; Lithobates blairi [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0136960 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human red blood cells
9 μM
LC50
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0159949 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
9.0 μM
HC50
PaperJ.M. Conlon et al. / Toxicon 53 (2009) 699-705. Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis
RECORD: Rec_0174898 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
RECORD: Rec_0180739 VERIFIED: YES
Provenance & Taxonomy
Lithobates blairi [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
25 μM
MIC
PMID19254736 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19254736/
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