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MYP_111370
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Basic Information
Cinnamycin
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C89H133N25O28S3
Standard
Sequence
CRQSCSFGPFTFVCDGNTK
Physicochemical Analysis
2097.35 Da
7.96
0.73
0.48
0.0384
-0.22
0.28
-0.02
77.73
15.26
0.1579
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
870.65
-12.18
33.0
32.0
65.0
145.0
4.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064761 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0093011 VERIFIED: YES
Provenance & Taxonomy
Streptomyces cinnamoneus cinnamoneus [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Methyllanthionine rings between residues 1 and18 as well as between residues 5 and 11; a lanthionine occurs between Cys14 and residue 4. In addition, addition of Lys19 to dehydralanine at position 6 forms a lysinoalanine bridge. The Asp residue at position 15 is hydroxylated. MOA:bacteria: Duramycins and cinnamycin specifically binds to phosphatidylethanolamine, thereby indirectly inhibiting the activity of phospholipase A2. Structure: Structure of cinnamycin complexed with lysophosphatidylethanolamine has been solved. You can rotate, zoom, and view the Greek key-like beta sheet structure here in the PDB. Updated 12/2024
Bio-Activity Profile
Antimicrobial Antifungal
PaperDuramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin
RECORD: Rec_0184036 VERIFIED: YES
Provenance & Taxonomy
Streptoverticillium griseoverticillatum [Fungus]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Herpes Simplex Virus
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ3950
RECORD: Rec_0202584 VERIFIED: YES
Provenance & Taxonomy
Streptomyces griseoverticillatus [Bacterium]
type B lantibiotic family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-Asp: (3R)-3-hydroxyaspartate
Bio-Activity Profile
Antimicrobial type B lantibiotic family Antibacterial Host defense
PaperPDB 2DDE structural record; NMR; chain A; residues 1-19
RECORD: Rec_0227066 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 10.5%, T 63.2%, C 26.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Toxic Antimicrobial Antifungal Anti-Gram-positive Cytotoxic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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