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MYP_111364
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Basic Information
A12V/A15H
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
25 amino acids
C140H232N52O27
Standard
Sequence
FIHHIIGGLFSVGKHIHRLIRRRRR
Physicochemical Analysis
3075.67 Da
12.00
7.11
6.70
0.2843
-0.23
1.02
-0.18
144.42
120.80
0.0800
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1294.09
-9.04
50.0
38.0
105.0
219.0
6.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0321679 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
16 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0358521 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
128 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0365123 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
mouse red blood cells
25 μg/mL
Hemolysis
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0388030 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
16 μg/mL
MIC
PaperHydrophobic residues are critical for the helix-forming, hemolytic and bactericidal activities of amphipathic antimicrobial peptide TP4. PLoS One. 2017 Oct 17;12(10):e0186442. doi: 10.1371/journal.pone.0186442. PMID: 29040295. PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
RECORD: Rec_0396571 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
128 μg/mL
MIC
PMID29040295 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29040295/
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