Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length533 amino acids

Chemical FormulaC2640H4171N747O725S17

DescriptionStandard

        PGSYRCPGAYGGLRARAHLLSSAALRMWLCLLLLLAACVPTTTSSPGIKGRVTRSALEYGRRFGLELLRSLLQKEHSVNLQGSYRAPLLGRLNYTVPQIHIHELQMNDSTVDFAEDVGVQLTVHRAQIQLNATWRAQLGAWQDSGSVQLHIRDLAVAVLLGLGADEHGHPSMWAAGCDAHGTDLHLEFYQGQSWLYNLLVPLLQRTLRQQLNKQLCVEIQKGISRLQDRLKNVQVSAQLDPFAAIDLSLLGQPAITKQHGDIDLKGEFFGVRGQWRSPFSAKPVGLPELHEPMLLVAVTEFVANTAAFVYFTAGALRRNITAEMLPRRFPLKLKTESMGNFAPQLQQHFPNRPVELHLWARRQPLLSCHPNALHGALFGSAEAFVVLPNATRVPAFLLNIDANVTGKPTIAGNRLGGTVGLKSLSVVQVRSHVGPLQVSGGDGTTMGYWGGEVTTPCMGPESKVPSGFPGILQVEKLENMLKFGLWLFGVPWANKQLRPGVPLPTPHGITLLRPRLSLHEGFMLIATDLHYEP
    

Molecular Weight58520.03 Da

Isoelectric Point (pI)9.38

Net Charge (pH 7.0)12.69

Net Charge (pH 7.4) 11.43

Charge Density (pH 7.0) 0.0238

GRAVY Index-0.03

Hydrophobic Moment 0.79

Boman Index0.10

Instability Index46.25

Aliphatic Index 99.36

Aromaticity 0.0750

Extinction Coeff. Reduced 69900.00

Extinction Coeff. Oxidized 70275.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0339363 VERIFIED: NO

Provenance & Taxonomy

OrganismColinus virginianus [Animal]

FamilyBPI

Tax ID9014

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence