Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length481 amino acids

Chemical FormulaC2396H3787N613O702S19

DescriptionStandard

        MRKMLKICCSLILLSLLSGLLSANPGVKVRITQKGLEYAREVGLEILKQNMEKEHFPDLTGHEKFGLGNVKYNISRIHVTAVELPSASISLLPGSGIKLVIGNASLTIDMNWNIRTWMFKDSGRGTVHISKVFVTAILSTPLDNAGPTSIALTSCRTTPGDVNIKLNGKTGFLYNFFIKYLKKPIHRSLVTNSCPNIRAGIQLIDGDLRSPNAVMQIDDLAEVDYSLSGLPAVFQTFIDLDLKGVVFPAGNHTDSPYMAASFTIPDQSDSMLYLAFSEYFFQSSSFAYYTAGAFNMTIAEETCSYFNINTEIFSSIIPEVAKYSITPYPVMLKLMSTEIPTISLQQDSFTAEIQGSVEVLAILPDSTTQSLFTLNIAANTSISLNIFDQKLMGSLCLNRIQFSLAHSNVGSFEVVLLENILSYIFQTEVIPSANAKLSKGFPLPNLANVTLTRPHIAIVQGYVLISTDAHYKHYRRRETTC
    

Molecular Weight53021.62 Da

Isoelectric Point (pI)6.79

Net Charge (pH 7.0)-0.66

Net Charge (pH 7.4) -1.59

Charge Density (pH 7.0) -0.0014

GRAVY Index0.16

Hydrophobic Moment 0.77

Boman Index0.16

Instability Index42.79

Aliphatic Index 101.98

Aromaticity 0.0915

Extinction Coeff. Reduced 36330.00

Extinction Coeff. Oxidized 36705.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0123008 VERIFIED: NO

Provenance & Taxonomy

OrganismJunco hyemalis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence