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MYP_111185
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Basic Information
2IH3
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
21 amino acids
C126H173N51O22
Standard
Sequence
IHHIHHHIHHIHHHIHHIHHH
Physicochemical Analysis
2754.05 Da
7.46
1.07
0.11
0.0508
-1.00
0.54
0.11
149.40
111.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1075.52
-5.14
37.0
37.0
83.0
199.0
15.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205516 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
α-helical synthetic linear peptide (about 95% α-helix in 50% TFE/H2O) [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli 25922
2 μM
MIC
PaperHighly Stabilized α-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition PMID31199117 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31199117/
RECORD: Rec_0239048 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
α-helical synthetic linear peptide (about 95% α-helix in 50% TFE/H2O) [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Cytotoxic
HEK293T cells
108.3; 102.8; 104.4; 102.2; 105; 105.3; 103.3 %
Cell viability assay at 2; 4; 8; 16; 32; 64; 128 μM (pH 7.4; values correspond in order)
PaperHighly Stabilized α-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition PMID31199117 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31199117/
RECORD: Rec_0340139 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
α-helical synthetic linear peptide (about 95% α-helix in 50% TFE/H2O) [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Cytotoxic
HEK293T cells
102.5; 104.5; 105.6; 103.7; 102.0; 103.1; 103.1 %
Cell viability assay at 2; 4; 8; 16; 32; 64; 128 μM (pH 6.0; values correspond in order)
PaperHighly Stabilized α-Helical Coiled Coils Kill Gram-Negative Bacteria by Multicomplementary Mechanisms under Acidic Condition PMID31199117 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31199117/
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