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MYP_111184
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Basic Information
Brevinin-2-OA8
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C138H240N40O48S2
Standard
Sequence
GVLATVKNLLNGTGDGAAQSVLKTLSCKLSNDC
Physicochemical Analysis
3291.75 Da
8.03
0.74
0.50
0.0224
0.21
0.49
0.11
14.60
106.36
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1440.92
-20.05
51.0
51.0
113.0
228.0
0.0
36.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076363 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus pyocyaneus CMCCB 10104
15.8 μg/mL
MIC
PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0090198 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 2002
4 μg/mL
MIC
PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0103553 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0109555 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
human red blood cells at the concentration of 50 μg/mL
50 μg/mL
Hemolysis
PaperExtremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. J Proteome Res. 2012 Jan 1;11(1):306-19. doi: 10.1021/pr200782u. PMID: 22029824. PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
RECORD: Rec_0156170 VERIFIED: YES
Provenance & Taxonomy
Odorrana andersonii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
1.22 μM
MIC
PaperX. Yang et al. / Journal of Proteome Research 11 (2012) 306-319. Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs PMID22029824 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22029824/
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