Peptide Database

Peptide NameFungal defensin scedosporisin-2 (fDEF)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC443H688N120O131S8

DescriptionStandard

        MKFSNISIAALFTILASTAMAAPAADSPDSIVAREPAPVEETYEAPSGLEKRGFGCPGSEKKCHNHCKSVKGYKGGYCDGPYIPFVGRPRCKCY
    

Molecular Weight10047.45 Da

Isoelectric Point (pI)8.55

Net Charge (pH 7.0)2.62

Net Charge (pH 7.4) 2.19

Charge Density (pH 7.0) 0.0279

GRAVY Index-0.28

Hydrophobic Moment 0.45

Boman Index0.03

Instability Index57.33

Aliphatic Index 57.23

Aromaticity 0.0957

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7825.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3949.19

LogP -41.81

H-bond Donors 141.0

H-bond Acceptors 144.0

Rotatable Bonds 319.0

Heavy Atoms 702.0

Ring Count 20.0

Amide Bonds 95.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0188535 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudallescheria apiosperma [other]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Anti-MRSA Anti-Gram-positive Cytotoxic Hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0416914 VERIFIED: NO