Peptide Database

Peptide NameSLAY-screened peptide P4749

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC92H151N27O30S

DescriptionStandard

        LHCSLAIPSLRPASHETLDS
    

Molecular Weight2147.41 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0536

GRAVY Index0.04

Hydrophobic Moment 0.34

Boman Index0.08

Instability Index56.21

Aliphatic Index 107.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 893.65

LogP -10.29

H-bond Donors 32.0

H-bond Acceptors 32.0

Rotatable Bonds 66.0

Heavy Atoms 150.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0034092 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/