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MYP_111097
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Basic Information
ChaC7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
28 amino acids
C127H204N32O37S6
Standard
Sequence
IPCGESCVWIPCITAIAGCSCKNKVCYT
Physicochemical Analysis
2963.56 Da
7.77
0.70
0.40
0.0250
0.75
0.27
0.28
29.37
83.57
0.0714
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1080.81
-10.71
43.0
44.0
90.0
202.0
5.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0249006 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Escherichia coli
6.4 μM
MIC
PaperNovel Cyclotides and Uncyclotides with Highly Shortened Precursors from Chassalia chartacea and Effects of Methionine Oxidation on Bioactivities.
RECORD: Rec_0258813 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic Anti-Gram-negative
Escherichia coli
6.4 μM
MIC
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0269942 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
11.6 μM
Hemolysis
PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0298330 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 60.7%, E 0.0%, T 28.6%, C 10.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Cytotoxic Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0303765 VERIFIED: YES
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
137261
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Hemolytic Anti-Gram-positive
Staphylococcus epidermidis
80 μM
MIC
PaperNovel cyclotides and uncyclotides with highly shortened precursors from Chassalia chartacea and effects of methionine oxidation on bioactivities PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
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