Peptide Database

Peptide NameyoaW signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory expression optimization

Enzyme / Catalytic activity ▸ Protease ▸ Bacillus protease novo type (BPN') secretion

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC127H208N30O31S4

DescriptionStandard

        MKKIVCLMVFSIMTAFGIHIQPAEA
    

Molecular Weight2779.45 Da

Isoelectric Point (pI)7.98

Net Charge (pH 7.0)0.58

Net Charge (pH 7.4) 0.29

Charge Density (pH 7.0) 0.0231

GRAVY Index1.12

Hydrophobic Moment 0.31

Boman Index0.42

Instability Index43.88

Aliphatic Index 113.20

Aromaticity 0.0800

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 954.50

LogP -3.83

H-bond Donors 33.0

H-bond Acceptors 37.0

Rotatable Bonds 92.0

Heavy Atoms 192.0

Ring Count 4.0

Amide Bonds 25.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006027 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus licheniformis DSM 13 = ATCC 14580 [Bacterium]

FamilySec signal peptide

Tax ID279010

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Bacillus protease novo type (BPN') secretion

TargetBacillus subtilis TEB1030

Activity3.49 U/mL

MethodProtease activity assay

PaperDegering C, Eggert T, Puls M, et al. Optimization of Protease Secretion in Bacillus subtilis and Bacillus licheniformis by Screening of Homologous and Heterologous Signal Peptides[J]. Applied and Environmental Microbiology, 2010, 76(19): 6370-6376. PMID20709850 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20709850/