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MYP_111064
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Basic Information
FP4(FCoV Sgp (1338-1380))
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
43 amino acids
C218H348N56O72
Standard
Sequence
FNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNL
Physicochemical Analysis
4905.43 Da
4.19
-5.14
-5.41
-0.1195
-0.01
0.55
0.11
39.50
126.98
0.0698
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2106.46
-20.00
70.0
68.0
165.0
346.0
4.0
49.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039092 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Fusion inhibition
feline coronavirus (FCoV) | Fcwf-4 cells
1.8 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperPeptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection. | Liu IJ, Tsai WT, Hsieh LE, Chueh LL. | PLoS One. 2013 Dec 3;8(12):e82081. | DOI:10.1371/journal.pone.0082081 | PMID:24312629 PMID24312629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24312629/
RECORD: Rec_0123397 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Fcwf-4 cells
>=200 μM
Cytotoxicity
PMID24312629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24312629/
RECORD: Rec_0147344 VERIFIED: YES
Provenance & Taxonomy
Feline coronavirus [Virus]
HR2-derived fusion inhibitor
33734
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline coronavirus
1.8 μM
IC50
PaperPeptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection PMID24312629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24312629/
RECORD: Rec_0152228 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Fcwf-4 cell
200 μM
CC50
PMID24312629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24312629/
RECORD: Rec_0159376 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline Coronavirus (FCoV)
90-100 % REP
REP
PMID24312629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24312629/
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