Peptide Database

Peptide NameSLAY-screened peptide P5494

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H165N29O29S2

DescriptionStandard

        HLPCYPYFFRTRSPQMYTPT
    

Molecular Weight2505.87 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)1.83

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.0917

GRAVY Index-0.76

Hydrophobic Moment 0.33

Boman Index-0.05

Instability Index82.69

Aliphatic Index 19.50

Aromaticity 0.2500

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 918.24

LogP -6.41

H-bond Donors 33.0

H-bond Acceptors 34.0

Rotatable Bonds 68.0

Heavy Atoms 177.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0066594 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/