Peptide Database

Peptide NameCirculin B

Function Ontology

Antiparasitic ▸ Anthelminthic

Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity

Insecticidal/Pest control ▸ Insecticidal activity

Standard StatusStandard

Sequence Length31 amino acids

Chemical FormulaC137H221N35O44S6

DescriptionStandard

        GVIPCGESCVYLPCLTTIVGCSCKNNVCYTN
    

Molecular Weight3254.82 Da

Isoelectric Point (pI)5.96

Net Charge (pH 7.0)-0.30

Net Charge (pH 7.4) -0.60

Charge Density (pH 7.0) -0.0097

GRAVY Index0.64

Hydrophobic Moment 0.32

Boman Index0.26

Instability Index23.19

Aliphatic Index 87.74

Aromaticity 0.0645

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1252.94

LogP -15.12

H-bond Donors 48.0

H-bond Acceptors 50.0

Rotatable Bonds 99.0

Heavy Atoms 222.0

Ring Count 4.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0124651 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

RECORD: Rec_0159392 VERIFIED: YES

Provenance & Taxonomy

OrganismClitoria ternatea [Plant]

FamilyCyclotide

Tax ID43366

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Insecticidal Nematocidal Anthelmintic

TargetCaenorhabditis elegans