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MYP_110943
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Basic Information
Linear Cyclotide Panitide L4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
27 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XAFCGETCLLGTCYTPGCRCTAGICLK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0115786 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Animal]
Cyclotide
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
modified/noncanonical-residue peptide [Modified]
N-terminal pyroglutamic acid
None
X=PYA (Pyroglutamic acid)
Bio-Activity Profile
Cyclotide Non-antimicrobial Non-cytotoxic
Tumor cells: HeLa
- -
Cytotoxicity assay (no cytotoxicity detected)
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0152756 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
modified/noncanonical-residue peptide [Modified]
N-terminal pyroglutamic acid
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Cyclotide Non-antimicrobial Non-cytotoxic
Human cervical carcinoma HeLa
Cytotoxicity assay (no cytotoxicity detected)
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0235804 VERIFIED: YES
Provenance & Taxonomy
Panicum laxum [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
modified/noncanonical-residue peptide [Modified]
N-terminal pyroglutamic acid
4-18, 8-20, 13-25.
Bio-Activity Profile
Cyclotide Non-antimicrobial Non-cytotoxic
Qualitative experimental inactivity evidence
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