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MYP_110943
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Basic Information
Linear Cyclotide Panitide L4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
27 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XAFCGETCLLGTCYTPGCRCTAGICLK
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027765 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Escherichia coli
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0054617 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0076761 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida albicans
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0095743 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Animal]
Cyclotide
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=PYA (Pyroglutamic acid)
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0113015 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida tropicalis
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
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