Peptide Database

Peptide NameAflibercept

Function Ontology

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1261H2023N341O381S12

DescriptionStandard

        SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED
    

Molecular Weight28441.39 Da

Isoelectric Point (pI)7.62

Net Charge (pH 7.0)1.21

Net Charge (pH 7.4) 0.37

Charge Density (pH 7.0) 0.0048

GRAVY Index-0.28

Hydrophobic Moment 0.63

Boman Index0.00

Instability Index34.82

Aliphatic Index 86.27

Aromaticity 0.0627

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20315.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0297327 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyFusion protein

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-angiogenic VEGF trap

Half-LifeIntravitreal half life - 7.13 d