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MYP_110899
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Basic Information
Trialysin (16-43)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C129H240N36O30S
Standard
Sequence
VGKVLKQLKKVSAVAKVAMKKGAALLK
Physicochemical Analysis
2807.57 Da
10.85
7.73
7.50
0.2861
0.40
0.74
0.05
-13.06
130.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1091.40
-7.13
38.0
39.0
105.0
196.0
0.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0065489 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
>2500 μg/mL
Hemolysis
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0078591 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 59.3%, E 0.0%, T 29.6%, C 11.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiparasitic Toxic Antimicrobial Cytotoxic Antitrypanosomal
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
RECORD: Rec_0138519 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Hemolytic
Human erythrocytes
900 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/16460023/ PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0140770 VERIFIED: YES
Provenance & Taxonomy
Triatoma infestans [Animal]
Trialysin
30076
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Cytolytic Antiparasitic Anti-Trypanosoma cruzi
Trypanosoma cruzi
19 μM
LC50; Microscopy (Surviving parasites counted by Neubauer hemocytometer)
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
RECORD: Rec_0151858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiparasitic Antiprotozoal
Escherichia coli DH5alpha
141 μg/mL
LC50
PMID16460023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16460023/
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