Peptide Database

Peptide NameTL6

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length199 amino acids

Chemical FormulaC1041H1603N259O285S13

DescriptionStandard

        MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
    

Molecular Weight22723.27 Da

Isoelectric Point (pI)7.62

Net Charge (pH 7.0)0.89

Net Charge (pH 7.4) 0.29

Charge Density (pH 7.0) 0.0045

GRAVY Index0.06

Hydrophobic Moment 0.50

Boman Index0.16

Instability Index38.89

Aliphatic Index 96.03

Aromaticity 0.1156

Extinction Coeff. Reduced 41940.00

Extinction Coeff. Oxidized 42315.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8656.81

LogP -100.82

H-bond Donors 297.0

H-bond Acceptors 304.0

Rotatable Bonds 702.0

Heavy Atoms 1598.0

Ring Count 46.0

Amide Bonds 221.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178317 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residues at positions 151 and 183; disulphide bond formation between cysteine residues at positions 80 and 100

Bio-Activity Profile

Function

Immunomodulatory Signaling peptide

Targetglucocorticoid-induced TNF receptor (Human)