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MYP_110825
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Basic Information
Sapecin (defensins; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
40 amino acids
C164H272N58O52S6
Standard
Sequence
ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN
Physicochemical Analysis
4080.66 Da
8.69
2.91
2.53
0.0727
0.10
0.53
0.03
16.61
75.75
0.0250
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1778.11
-26.16
69.0
63.0
133.0
280.0
3.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0340137 VERIFIED: NO
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
Disulfide-stabilized peptide [Linear]
noncanonical stereochemical modification [Modified]
three disulfide bonds
Bio-Activity Profile
Antimicrobial
PaperABC Transporter DerAB of Lactobacillus casei Mediates Resistance against Insect-Derived Defensins PMID32414796 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32414796/
RECORD: Rec_0343187 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Streptococcus uberis, Lactococcus lactis
3 μg/mL
MIC
PaperMolecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina. PMID3182837
RECORD: Rec_0346523 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
S. salivarius HHTt
2.6 μg/mL
IC50
PaperMolecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina. PMID3182837
RECORD: Rec_0355392 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-38
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Mycobacterium smegmatis ATCC607
78 μg/mL
MIC
PMID3182836;2358424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
RECORD: Rec_0367198 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Corynebacterium michiganense
2.5 μg/mL
MIC
PMID3182836 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
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