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MYP_110825
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Basic Information
Sapecin (defensins; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
40 amino acids
C164H272N58O52S6
Standard
Sequence
ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN
Physicochemical Analysis
4080.66 Da
8.69
2.91
2.53
0.0727
0.10
0.53
0.03
16.61
75.75
0.0250
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1778.11
-26.16
69.0
63.0
133.0
280.0
3.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0126205 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-38
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus FDA16
1.2 μg/mL
MIC
PMID3182836;2358424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
RECORD: Rec_0127744 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
invertebrate defensin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-30; 16-36; 20-38
Bio-Activity Profile
Antimicrobial invertebrate defensin family Antibacterial Host defense Defensin-like
PaperPDB 1L4V structural record; NMR; chain A; residues 1-40
RECORD: Rec_0128707 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Natural peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium smegmatis ATCC 607
MIC
PMID3182836 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
RECORD: Rec_0134808 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus epidermidis IFO 3762
1.0 μg/mL
IC50
PaperMolecular cloning of cDNA for sapecin and unique expression of the sapecin gene during the development of Sarcophaga peregrina.
RECORD: Rec_0136804 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-38
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus IF03333
1.2 μg/mL
MIC
PMID3182836;2358424 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3182836/
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