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MYP_110794
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Basic Information
hEP-8
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
25 amino acids
C132H235N47O37
Standard
Sequence
EELRVRLASHLRKLRKRLLRDADDL
Physicochemical Analysis
3072.57 Da
10.74
2.93
2.70
0.1171
-0.88
0.73
-0.53
59.70
128.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1420.57
-12.00
53.0
41.0
111.0
216.0
1.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027926 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus (HCVpp) | Huh7.5.1 cells
10 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperHuman apolipoprotein E peptides inhibit hepatitis C virus entry by blocking virus binding. | Liu S, McCormick KD, Zhao W, Zhao T, Fan D, Wang T. | Hepatology. 2012 Aug;56(2):484-91. | DOI:10.1002/hep.25665 | PMID:22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0042732 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
cells
10 μM
IC50
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0074362 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0141905 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
hepatitis C virus(HCVpp):inhibition of infection in Huh7
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
RECORD: Rec_0248250 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5
PaperPubMed PMID: 22334503 PMID22334503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22334503/
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