Peptide Database

Peptide NameSLAY-screened peptide P5404

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC75H102N20O24S

DescriptionStandard

        HNTYCNTPYSYHSL
    

Molecular Weight1699.80 Da

Isoelectric Point (pI)6.90

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0056

GRAVY Index-1.11

Hydrophobic Moment 0.17

Boman Index-0.04

Instability Index22.89

Aliphatic Index 27.86

Aromaticity 0.2143

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 717.98

LogP -8.54

H-bond Donors 26.0

H-bond Acceptors 27.0

Rotatable Bonds 47.0

Heavy Atoms 120.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103620 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/