Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length480 amino acids

Chemical FormulaC2352H3783N609O686S18

DescriptionStandard

        MFLWCVLVLVSLVSVATGTSAGVKVRLTQKGLEYGRQIGIASIQQKLRTIKVPDISGTEKVDPIGKVQYSFTGMQIVNLGLPKSALALVPDTGVILSIGNAYINLHGNWRVKYLRIIKDSGSFDLAVSELTISTTVAVTSDDTGRPTVSMTNCAATVGSVNVKFHGGASWLYNLFSSFINKALRNALQKQICPLVADSVADINPHLKTLNVLAKVDQYAEIEYSMVGSPVISNTSIDLGLKGEFYNIGQHKEPPFSPTPFSLPSQDTDMLYIGVSAFTINSAGFVYNRAGALRLYITDDMIPSGSPIRLNTKTFGGFIPQIEKMYPGLMMKLLVETVKEPLMTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEGSVSTHIYVTELKLAGNVTLNKIDMSLAKSYVGPFQVTSLDNIFTIVLKFAVIPKVNARLQEGYPLPAIGKMQLVNSQLQVLKVKTGTDIGQITRGRQMSTMR
    

Molecular Weight52145.03 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)9.92

Net Charge (pH 7.4) 9.31

Charge Density (pH 7.0) 0.0207

GRAVY Index0.17

Hydrophobic Moment 0.72

Boman Index0.16

Instability Index31.65

Aliphatic Index 103.10

Aromaticity 0.0771

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0398709 VERIFIED: NO

Provenance & Taxonomy

OrganismSinocyclocheilus grahami (Dianchi golden-line fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria