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MYP_110592
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Basic Information
Bass hepcidin (fish, chordates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C86H135N29O25S9
Standard
Sequence
GCRFCCNCCPNMSGCGVCCRF
Physicochemical Analysis
2263.76 Da
8.23
1.68
1.36
0.0800
0.58
0.42
0.06
38.25
13.81
0.0952
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
866.74
-12.90
38.0
36.0
69.0
149.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0307063 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
Klebsiella pneumoniae ATCC 10
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0333316 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
shigelloides ATCC KST
11 μM
MIC
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0357398 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
PMID11985602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0379761 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
Escherichia coli ATCC 25
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0414474 VERIFIED: YES
Provenance & Taxonomy
Dicentrarchus labrax [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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