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MYP_110592
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Basic Information
Bass hepcidin (fish, chordates, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C86H135N29O25S9
Standard
Sequence
GCRFCCNCCPNMSGCGVCCRF
Physicochemical Analysis
2263.76 Da
8.23
1.68
1.36
0.0800
0.58
0.42
0.06
38.25
13.81
0.0952
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
866.74
-12.90
38.0
36.0
69.0
149.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015046 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal Hemolytic
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0020717 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
22 μM
MIC
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0063549 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
It displays essentially no hemolytic activity toward HSB erythrocytes
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
RECORD: Rec_0068081 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops x Morone saxatilis [Animal]
hepcidin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-19; 5-8; 6-15; 9-18
Bio-Activity Profile
Antimicrobial hepcidin family Antibacterial Host defense
PaperPDB 1S6W structural record; NMR; chain A; residues 1-21
RECORD: Rec_0079814 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Hepcidin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 5-8, 6-15, 9-18
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Antifungal
Shigella sonnei ATCC 9290
44 μM
MIC
PMID11985602;15546886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11985602/
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