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MYP_110553
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Basic Information
Brevinin-1AN1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
23 amino acids
C111H194N26O28S2
Standard
Sequence
FLTGVLKLASKIPSVLCAVLKTC
Physicochemical Analysis
2405.02 Da
9.39
2.74
2.50
0.1190
1.34
0.58
0.37
-1.77
148.26
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
853.71
-5.28
32.0
33.0
79.0
167.0
2.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0124979 VERIFIED: YES
Provenance & Taxonomy
Babina adenopleura [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
17-23
Bio-Activity Profile
Antimicrobial
fungi Candida albicans ATCC 10231
>150 μM
MIC
PaperDiverse Families of Antimicrobial Peptides Isolated from Skin Secretions of Three Species of East Asian Frogs, Babina daunchina, Babina adenopleura, and Rana omeimontis (Ranidae).
RECORD: Rec_0136175 VERIFIED: YES
Provenance & Taxonomy
Babina adenopleura [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0141239 VERIFIED: YES
Provenance & Taxonomy
Babina adenopleura [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
17-23
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923
19 μM
MIC
PaperDiverse Families of Antimicrobial Peptides Isolated from Skin Secretions of Three Species of East Asian Frogs, Babina daunchina, Babina adenopleura, and Rana omeimontis (Ranidae).
RECORD: Rec_0144217 VERIFIED: YES
Provenance & Taxonomy
Babina adenopleura [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus licheniformis X39
37.5 μM
MIC
PMID25001915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25001915/
RECORD: Rec_0154197 VERIFIED: YES
Provenance & Taxonomy
Babina adenopleura [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Psychrobacter faecalis X29
37.5 μM
MIC
PMID25001915 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25001915/
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