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MYP_110545
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Basic Information
Brevinin-1JDc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C123H208N30O27S2
Standard
Sequence
FLPAVLRVAAKVVPTVFCLISKKC
Physicochemical Analysis
2603.28 Da
9.85
3.74
3.50
0.1557
1.33
0.63
0.32
46.17
137.92
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
895.46
-3.55
33.0
33.0
82.0
182.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0233780 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
128 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0260693 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0271910 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Extended-spectrum-lactamases Escherichia coli
64 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0289282 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0302973 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
rabbit red blood cells
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
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