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MYP_110543
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Leucyltransferase Inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
2 amino acids
C12H26N8O3
Standard
Sequence
RR
Physicochemical Analysis
330.39 Da
12.00
1.76
1.56
0.8800
-4.50
1.63
-2.53
291.40
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
216.22
-2.59
9.0
5.0
11.0
23.0
0.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0108153 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
3.57 pIC50
pIC50
PaperWhat are the ideal properties for functional food peptides with antihypertensive effect? A computational peptidology approach. PMID23871047 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23871047/
RECORD: Rec_0165571 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Neurotensin
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
PaperCain G. A., Christos T. E., Johnson A. L., Pottorf R. S., Tam S., Schmidt W. K.. Identification of simpler analogs of neurotensin(913) which retain antinociceptive activity. Bioorg. Med. Chem. Lett., 3, 1767-1772, 1993.
RECORD: Rec_0194704 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: amide; Conjugated small molecule: 3-(Benzyloxy)aniline
Bio-Activity Profile
Anticancer
PaperREPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. ChemBioChem. 2006 Evidence URLhttps://doi.org/10.1002/cbic.200600189
RECORD: Rec_0237608 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Source entry describes small-molecule/peptide conjugation at one terminus; exact terminus not explicitly assigned in source metadata
Conjugate type: sulfonamide; Conjugated small molecule: 2H-1-Benzopyran-6-sulfonic acid, 3,4-dihydro-2,2,5,7,8-pentamethyl-
Bio-Activity Profile
Anticancer
PaperREPLACE: a strategy for iterative design of cyclin-binding groove inhibitors. ChemBioChem. 2006 Evidence URLhttps://doi.org/10.1002/cbic.200600189
RECORD: Rec_0259063 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
PaperNa H., Li X., Zou C., Wang C., Wang C., Liu K.. Triterpene sapogenin-polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains. Bioorg. Med. Chem., 24, 2999-3005, 2016.
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