Peptide Database

Peptide NameSC28EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC164H260N40O52

DescriptionStandard

        WEEWDKKIEEYTKKIEELIKKSEEQQKK
    

Molecular Weight3624.06 Da

Isoelectric Point (pI)5.33

Net Charge (pH 7.0)-1.23

Net Charge (pH 7.4) -1.46

Charge Density (pH 7.0) -0.0438

GRAVY Index-2.04

Hydrophobic Moment 0.69

Boman Index-0.49

Instability Index87.71

Aliphatic Index 55.71

Aromaticity 0.1071

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1571.33

LogP -9.60

H-bond Donors 53.0

H-bond Acceptors 51.0

Rotatable Bonds 135.0

Heavy Atoms 256.0

Ring Count 5.0

Amide Bonds 29.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0382545 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 HXB2 | TZM-bl cells

Activity0.013±0.0015 μM

MethodIC50

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0417303 VERIFIED: YES