Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2406H3831N619O654S12

DescriptionStandard

        DKGEKMLKIWYSFLLCLLSLQLEANPGLKVQITQKGLDYGKTIGMELLKEAILKETFPSWSGQESFAFVKVNYRISRLRINAVDFPETSASFIPGTGISLSVARASATISADWGLKTWLLRGQGGITVSLSGLFMAVVFEVSRDSTGHLSVLLHNCQLIINSVKVRLNGGSSWVYNFLSGYLEKAIHTKLGKNLCLDIKYKIQMLDAYLRKLKVLSQIDAFAQIDYSLVSSPAVFKSHLNLDLKGTVYAVGNRRDPPFVPAPFALPNQGDSMLYLGVSNYFLKSASLAYYRAGVFNITISRELATAFNLTTALFKKFLPQIARYYVAAHPVLLKLMATSPPEVSLQADGCSLQITGLVEVFAVLPNSAMQYIFTGHITANTRANLTVTKQKLIISLLLKRLQLSLVHSLARYSGISLVEDFLSYALQSVVIPVIHDKLGKGFPLPKLAHTILVRPVIKMNQGHLVISTDVHYK
    

Molecular Weight52277.69 Da

Isoelectric Point (pI)9.65

Net Charge (pH 7.0)20.68

Net Charge (pH 7.4) 19.76

Charge Density (pH 7.0) 0.0437

GRAVY Index0.27

Hydrophobic Moment 0.78

Boman Index0.17

Instability Index28.15

Aliphatic Index 113.57

Aromaticity 0.0973

Extinction Coeff. Reduced 55810.00

Extinction Coeff. Oxidized 56060.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0289464 VERIFIED: NO

Provenance & Taxonomy

OrganismTinamus guttatus [Animal]

FamilyBPI/LBP

Tax ID94827

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria