Peptide Database

Peptide NameSLAY-screened peptide P868

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC87H149N29O35S2

DescriptionStandard

        PMSSTVRLRTTNDDINSCTN
    

Molecular Weight2225.42 Da

Isoelectric Point (pI)6.34

Net Charge (pH 7.0)-0.05

Net Charge (pH 7.4) -0.12

Charge Density (pH 7.0) -0.0025

GRAVY Index-0.82

Hydrophobic Moment 0.50

Boman Index-0.27

Instability Index64.53

Aliphatic Index 53.50

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1071.51

LogP -17.93

H-bond Donors 40.0

H-bond Acceptors 37.0

Rotatable Bonds 73.0

Heavy Atoms 153.0

Ring Count 1.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0001999 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/