Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2326H3740N592O665S21

DescriptionStandard

        MSPCCLLALLAVISLTLAASPGVKVKLTDKGIEYGKQIGMASLQQKLKTIKVPDLSGTEKVPPIGKVKYSLTGMTIVNLGLPKSALVLMPGTGVRLAITNAFINLHGNWRVRYFRFIQDRGSFDLTVNGLTITADIAIKSDETGRPTVSTVNCVANVGSASIKFHGGASWLYNLFKSYIDKALRSALQKQICPLVADVITDMNPHLKTFNVLAKVDQYAEIEYSMVTSPTISKSSIEFSLKGEFYNIGKHREPPFSPTPFSLPPQDNNMLYIGVSSFTPNSAGFVYNNAGALSLYVTDDMIPPSSPIRLNTGTFGVFIPEIAKRFPGMMMKLLVKTVKEPTISLEPNNVTVQASGTVTAYAIQPNTTLSPLFVLNMEGSVSAQMNVTGVKLAGAITLNKIEMTLGTSYVGQFQVQPLDNIFLMVLKVVVIPKVNARLEKGFPLPTIGKMNLINTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51311.51 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)12.82

Net Charge (pH 7.4) 12.24

Charge Density (pH 7.0) 0.0271

GRAVY Index0.19

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index30.99

Aliphatic Index 101.14

Aromaticity 0.0782

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0288669 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus kisutch [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence