Peptide Database

Peptide Namegrowth/differentiation factor-3

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length114 amino acids

Chemical FormulaC576H882N154O160S12

DescriptionStandard

        AAIPVPKLSCKNLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDPEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG
    

Molecular Weight12908.88 Da

Isoelectric Point (pI)6.29

Net Charge (pH 7.0)-1.74

Net Charge (pH 7.4) -2.36

Charge Density (pH 7.0) -0.0153

GRAVY Index0.01

Hydrophobic Moment 0.58

Boman Index0.13

Instability Index62.67

Aliphatic Index 87.28

Aromaticity 0.0965

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 17335.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4953.83

LogP -41.60

H-bond Donors 171.0

H-bond Acceptors 176.0

Rotatable Bonds 412.0

Heavy Atoms 902.0

Ring Count 27.0

Amide Bonds 125.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0125405 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is predicted to be either a homodimer or a heterodimer, which cannot be disulphide linked. Predicted N-linked glycosylation of asparagine residue at position 56; predicted disulphide bond formation between cysteine residues at positions 14 and 79, 43 and 111, and 47 and 113

Bio-Activity Profile

Function

Receptor agonist Signaling peptide

TargetGrowth/differentiation factor receptors (Human)