Peptide Database

Peptide NameAlpha-mammal toxin AaH2

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC313H464N88O96S8

DescriptionStandard

        VKDGYIVDDVNCTYFCGRNAYCNEECTKLKGESGYCQWASPYGNACYCYKLPDHVRTKGPGRCH
    

Molecular Weight7252.08 Da

Isoelectric Point (pI)7.67

Net Charge (pH 7.0)0.83

Net Charge (pH 7.4) 0.38

Charge Density (pH 7.0) 0.0130

GRAVY Index-0.71

Hydrophobic Moment 0.46

Boman Index-0.10

Instability Index36.37

Aliphatic Index 41.09

Aromaticity 0.1406

Extinction Coeff. Reduced 15930.00

Extinction Coeff. Oxidized 16430.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2978.51

LogP -32.50

H-bond Donors 111.0

H-bond Acceptors 107.0

Rotatable Bonds 229.0

Heavy Atoms 505.0

Ring Count 15.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0278157 VERIFIED: YES

Provenance & Taxonomy

OrganismAndroctonus australis [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide12-63; 16-36; 22-46; 26-48

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense