Peptide Database

Peptide NameUnnamed

Function Ontology

Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Amylase inhibition ▸ Alpha-amylase inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-1 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ COX-2 Inhibitory

Enzyme modulation ▸ Enzyme inhibition ▸ Lipase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Lipoxygenase Inhibitory

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Metabolic ▸ Glucose metabolism ▸ Antidiabetic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC49H79N17O19

DescriptionStandard

        GNPVGGVGHGTTGT
    

Molecular Weight1210.25 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.41

Charge Density (pH 7.0) -0.0109

GRAVY Index-0.31

Hydrophobic Moment 0.24

Boman Index0.27

Instability Index-13.99

Aliphatic Index 41.43

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 565.29

LogP -10.71

H-bond Donors 19.0

H-bond Acceptors 20.0

Rotatable Bonds 35.0

Heavy Atoms 85.0

Ring Count 2.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0422697 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630.0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory COX-2 Inhibitory

TargetCyclooxygenase-2 (COX-2)

Activity3.66 μg/mL

MethodIC50

PaperZ?otek U., Jakubczyk A., Rybczy¨½ska-Tkaczyk K., ?wiek P., Baraniak B., Lewicki S.. Characteristics of new peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as inhibitors of enzymes involved in metabolic syndrome and antimicrobial potential. Molecules, 25, 2492, 2020. PMID32471271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32471271/

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