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MYP_110140
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Basic Information
Innate defence regulator peptide 1002
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Standard
12 amino acids
C79H129N25O14
Standard
Sequence
VQRWLIVWRIRK
Physicochemical Analysis
1653.03 Da
12.00
3.73
3.52
0.3111
-0.12
0.16
-0.20
60.11
145.83
0.1667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
669.81
-1.19
26.0
18.0
54.0
118.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Pseudomonas aeruginosa
6.053 μM
Confocal microscopy-fluorescence
PaperBroad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response PMID24852171 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24852171/
RECORD: Rec_0322377 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
RECORD: Rec_0350334 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Innate defense regulator / cationic host-defense peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Immunomodulatory Anti-inflammatory Anti-infective
Human neutrophils
PaperMechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model | The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions PMID28993516;23616580 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28993516/
RECORD: Rec_0397716 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
IDR
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibacterial Immunomodulatory
PaperBeyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives.FEMS Immunology & Medical Microbiology(2012) PMID22409572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22409572/
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