Peptide Database

Peptide NameIL-36 receptor antagonist

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length155 amino acids

Chemical FormulaC761H1181N197O224S9

DescriptionStandard

        MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
    

Molecular Weight16962.29 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-4.35

Net Charge (pH 7.4) -4.78

Charge Density (pH 7.0) -0.0281

GRAVY Index0.03

Hydrophobic Moment 0.52

Boman Index0.14

Instability Index60.09

Aliphatic Index 89.94

Aromaticity 0.0968

Extinction Coeff. Reduced 23950.00

Extinction Coeff. Oxidized 24200.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6684.24

LogP -62.47

H-bond Donors 231.0

H-bond Acceptors 231.0

Rotatable Bonds 550.0

Heavy Atoms 1191.0

Ring Count 29.0

Amide Bonds 168.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0167137 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted disulphide bond formation between cysteinen residues at positions 8 and 154.

Bio-Activity Profile

Function

Receptor antagonist Immunomodulatory Signaling peptide

TargetInterleukin-36 receptor (Human)