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MYP_110129
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Basic Information
PAMP (Proadrenomedullin N-terminal 20 peptide)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Reproductive biology ▸ Reproductive modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Angiogenic
Standard
20 amino acids
C112H177N35O28
Standard
Sequence
ARLDVASEFRKKWNKWALSR
Physicochemical Analysis
2461.82 Da
11.00
3.80
3.60
0.1898
-0.95
0.53
-0.35
39.26
68.50
0.1500
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1069.71
-8.52
40.0
32.0
83.0
175.0
5.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009549 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Melittin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-negative bacteria: Escherichia coli
8 μM
MIC
PMID32439180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32439180/
RECORD: Rec_0044223 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Melittin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis
8 μM
MIC
PMID32439180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32439180/
RECORD: Rec_0046312 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Melittin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
Note
PMID32439180 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32439180/
RECORD: Rec_0048936 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Proadrenomedullin N-20 terminal peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Vasoconstrictor Cardiovascular Metabolic regulation Physiological regulation Reproductive regulator Growth regulation Development regulation Myotropic Receptor modulation
pituitary gland
Mammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour
PMID16315141 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16315141/
RECORD: Rec_0093801 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
adrenomedullin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone adrenomedullin family Antibacterial Angiogenic Host defense
PaperPDB 2FLY structural record; NMR; chain A; residues 1-20
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