Peptide Database

Peptide NameFungal defensin triintsin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive ▸ Anti-Staphylococcus aureus

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length85 amino acids

Chemical FormulaC382H620N110O117S8

DescriptionStandard

        MQFTKLATVLIVSLMGSAAIAAPSVDNAPAVAAEEVAAAPAENLEKRGFGCPLNERECHSHCQSIGRKFGYCGGTLRLTCICGKE
    

Molecular Weight8882.20 Da

Isoelectric Point (pI)6.70

Net Charge (pH 7.0)-0.36

Net Charge (pH 7.4) -0.79

Charge Density (pH 7.0) -0.0043

GRAVY Index0.15

Hydrophobic Moment 0.55

Boman Index0.11

Instability Index40.88

Aliphatic Index 82.82

Aromaticity 0.0471

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3597.75

LogP -40.32

H-bond Donors 129.0

H-bond Acceptors 127.0

Rotatable Bonds 292.0

Heavy Atoms 617.0

Ring Count 10.0

Amide Bonds 89.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0060785 VERIFIED: YES

Provenance & Taxonomy

OrganismTrichophyton interdigitale [Fungus]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetKlebsiella pneumoniae

RECORD: Rec_0168867 VERIFIED: NO

Provenance & Taxonomy

OrganismTrichophyton interdigitale [Fungus]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0218630 VERIFIED: YES

Provenance & Taxonomy

OrganismTrichophyton interdigitale [Fungus]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0286285 VERIFIED: YES

Provenance & Taxonomy

OrganismTrichophyton interdigitale [Fungus]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Defensin Antifungal Anti-MRSA Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetCandida albicans