Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2284H3609N581O662S13

DescriptionStandard

        MLPYLVFLLLSLSTHTHGENPAIKLILTDKGLQYGKHLGAGFVQDRIKNMSFADIKGRIGLVKYVLSGVSVSQCDFPEPTVDFYEGIGFKAMISGLNIRVIGKLKIKFGFIHVGGSFDLAAFNVGVTSEVRLGDNEGHLSISSETCSAEIGDVNINFHGGASSISKMVISIFKDHFKGEIQGKICPAIKQQIEDLERQLVAIAVSFQVGSDLVLDVPLSSSPLVDSASLELDFKGEFYNAKSHTDPPFQVQNFSLTRQDSYMLSLGMSEFTANSVSYSYFSTGVLVAHITDKMIPTVFPLRLNTSSFGKLIPQLPKLFPDLLMELSVSARKVPMFSFLPGEVQLGLPGMVTAFAVQNNATLTPLFKLQADSVFSGQVSISGNKVQGSAALSNFTLTLVSSEIGPFKTTDLENLLRFGIKNGVLPKLNAKLEEGVVLPSSHHIQLVNPVLKVNKGFVDFSSNVAV
    

Molecular Weight50216.43 Da

Isoelectric Point (pI)6.60

Net Charge (pH 7.0)-1.53

Net Charge (pH 7.4) -2.45

Charge Density (pH 7.0) -0.0033

GRAVY Index0.22

Hydrophobic Moment 0.68

Boman Index0.18

Instability Index30.26

Aliphatic Index 102.65

Aromaticity 0.0884

Extinction Coeff. Reduced 11920.00

Extinction Coeff. Oxidized 12045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020619 VERIFIED: NO

Provenance & Taxonomy

OrganismOsmerus mordax [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence